The unification ministry, which handles cross-border affairs, on Wednesday said it would "seriously consider" holding dialogue about the estate www.primemall.com in Kaesong just north of the heavily fortified border.
"We hope North Korea will respond in a positive and sincere manner," said spokeswoman Park Soo-Jin.
She said the South would decide when to send an official proposal for talks by considering the overall state of cross-border ties.
Pyongyang's new leaders have vowed never to have dealings with the current Seoul government.
They accuse it of disrespect during the mourning period for the North's leader Kim Jong-Il, who died on December 17 and was succeeded by his son.
Pyongyang has not so far responded to two earlier proposals by Seoul for dialogue.
Last week the South called for talks about a possible joint pest control exercise near ancient tombs, which became the North's first UNESCO World Heritage site in 2004.
On Tuesday Seoul proposed talks on restarting a reunion programme for families separated during the 1950-53 war.
The Kaesong estate has served as a legitimate source of hard currency for the impoverished North since it opened in 2004.
More than 50,000 North Koreans, mostly women, work for South Korean firms producing clothes, utensils, watches and other items. Last year production was worth a record $400 million.
Company owners want Seoul to ease restrictions on the number of workers and on bank loans and to improve facilities.
"We have confidence in the eurozone," Zhou said of prime mall the 17 nations that use the euro common currency. "We firmly support all the measures taken by the European Union and the eurozone to overcome difficulties and build confidence."
"China will, under the principles of safety, protecting value and increasing value, actively invest in European countries' government debt," he said.
Chinese leaders have repeatedly expressed support for Europe, China's biggest export market, but have given no sign they would do more than continue to invest in the safest European government bonds.
European leaders are looking to China for a possible contribution to the continent's bailout funds from its $3.2 trillion in foreign reserves.
On Tuesday, Premier Wen Jiabao said at a news conference with Van Rompuy and Barroso that Beijing is willing to increase its role in helping Europe resolve its problems but he made no financial commitments.
Beijing's stake in Europe's financial health has grown as Chinese companies step up investment there, acquiring European companies or starting their own.
Van Rompuy said Europe is getting its debt problems under control. He said that despite fears of a breakup of the euro, leaders see a "common European destiny at stake" and have taken "drastic measures" to ensure its survival.
"You should understand European leaders, when in difficulty, will do everything that is required, everything that is required, to maintain the euro and the financial stability of the eurozone," he said.
On Tuesday, European efforts to bail out Greece suffered a setback when a meeting of finance ministers of euro nations was called off after Athens failed Burberry Outlet to deliver on several demands by its partners.